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potent and selective XPO1/CRM1 Inhibitor
Smiles: CCOC(=O)C1=CN=C2C=CC(=CN21)C1=CN=CC(=C1)NS(=O)(=O)C1C=CC=CC=1
Ponatinib HCl
InChi: InChI=1S/C44H59ClN10O8S/c1-28(2)23-34(51-43(60)40(57)33(46)24-31-10-6-5-7-11-31)41(58)47-13-18-61-19-20-62-21-22-63-27-38(56)55-16-14-54(15-17-55)37-25-36(49-30(4)50-37)52-44-48-26-35(64-44)42(59)53-39-29(3)9-8-12-32(39)45/h5-12
Selisistat S-enantiomer
IMR-1 - CAS# 310456-65-6 Size:10mg solid potent and selective XPO1/CRM1 InhibitorIMR 1 is a novel class of Notch inhibitors targeting the transcriptional activation with an IC50 of 26 M. IMR 1 prevents the recruitment of Mastermind like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth. Product information CAS Number: 310456 65 6 Molecular Weight: 353. 41 Formula: C15H15NO5S2 Chemical Name: ethyl 2 (2 methoxy 4 {[(5E) 4 oxo 2 sulfanylidene 1,
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