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Filippakopoulos
Smiles: CCOC(=O)/C=C/C(=O)NNC(=O)C1=CN=CC=C1CC1C=CC=CC=1
Omeprazole (H 16868) virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1
Smiles: [2H]C([C@]([2H])(NC(=O)[C@@H](NC)C(C)C)C(=O)N(C)[C@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1C=CC=CC=1)OC)[C@@H](C)CC)(C([2H])([2H])[2H])C([2H])([2H])[2H]
CAS Number: 732983-37-8
Lysine-specific Demethylase Inhibitor (1C) orine hydrochloride FilippakopoulosLysine specific Demethylase Inhibitor (1C) is a lysine specific demethylase inhibitor. Lysine specific demethylase 1 (LSD1) is the first of several protein lysine demethylases identified. Through a FAD dependent oxidative reaction, LSD1 could specifically remove histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor, LSD1 alters its substrates to H3K9me2. The LSD1 complex regulates a coordinated histone modification
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