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5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM
cyclic peptidomimetic that has been shown to be a partial TrkA receptor agonist
CCN1C2C(=CN=CC=2C(=O)N2CC[C@H](N)C2)N=C1C1=NON=C1N
6-dihydropyrimidin-2-amine hydrochloride
NPJ Breast Cancer
MG-277 164015 5-induced luciferase expression in TM3-Gli-LucMG 277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1. 3 nM. MG 277 potently inhibits tumor cell growth in a p53 independent manner, with IC50s of 3. 5 nM for RS4; 11 cells and 3. 4 nM for p53 mutant RS4; 11 IRMI 2 cells, respectively. Anticancer activity. Product information CAS Number: 2411085 89 5 Molecular Weight: 774. 71 Formula: C41H42Cl2FN5O5 Chemical Name: (3'R,4'S,5'R)
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