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Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system
56(19):7498-500
and represses tumor growth
SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4
Formula: C24H26N6O3
P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid Resistance analysis of the hepatitisP5091 (P005091), CAS No. 882257 11 6, is a novel potent and selective inhibitor of ubiquitin specific protease 7 (USP7) with an IC50 ~4. 2 M. It does not inhibit other DUBs or other families of cysteine proteases tested (EC50 > 100 mM). It induces apoptosis in MM cells resistant to conventional and bortezomib therapies. Biochemical and genetic studies showed that blockade of HDM2 and p21 abrogated P5091 induced cytotoxicity. In animal tumor model